Heat-Labile Enterotoxin: Beyond G M1 Binding
نویسندگان
چکیده
منابع مشابه
Heat-Labile Enterotoxin: Beyond GM1 Binding
Enterotoxigenic Escherichia coli (ETEC) is a significant source of morbidity and mortality worldwide. One major virulence factor released by ETEC is the heat-labile enterotoxin LT, which is structurally and functionally similar to cholera toxin. LT consists of five B subunits carrying a single catalytically active A subunit. LTB binds the monosialoganglioside G(M1), the toxin's host receptor, b...
متن کاملantibody against recombinant heat labile enterotoxin b subunit (rltb) could block lt binding to ganglioside m1 receptor
objectives: enterotoxigenic escherichia coli (etec) is one of the most common agents of diarrhea among other bacterial agents. designing and producing vaccine against these bacteria is one of the major purposes of world health organization (who). due to presence of diverse clones of etec strains in the world, the use of global vaccines for etec infection is controversial. b subunit of heat labi...
متن کاملAntibody against recombinant heat labile enterotoxin B subunit (rLTB) could block LT binding to ganglioside M1 receptor
OBJECTIVES Enterotoxigenic Escherichia coli (ETEC) is one of the most common agents of diarrhea among other bacterial agents. Designing and producing vaccine against these bacteria is one of the major purposes of World Health Organization (WHO). Due to presence of diverse clones of ETEC strains in the world, the use of global vaccines for ETEC infection is controversial. B subunit of heat labil...
متن کاملHeat - labile Enterotoxin of Escherichia coli
Heat-labile enterotoxin (LT) was obtained in large quantities (several-gram amounts) and great purity from Escherichia coli C600 carrying the LT-coding multicopy plasmid EWD299. By growing this strain on a medium that allows high cell densities in the early stationary phase, we increased the net LT production per milliliter by a factor of 200, compared to natural porcine enterotoxigenic E. coli...
متن کاملEscherichia coli Heat - labile Enterotoxin NUCLEOTIDE SEQUENCE
We report the complete DNA sequence of the Escherichia coli elt A gene, which codes for the A subunit of the heat-labile enterotoxin, LT. The amino acid sequence of the LT A subunit has been deduced from the DNA sequence of elt A. The LT A subunit starts with methionine, ends with leucine, and comprises 264 amino acids. The computed molecular weight of LT A is 29,673. The A subunit of cho...
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ژورنال
عنوان ژورنال: Toxins
سال: 2010
ISSN: 2072-6651
DOI: 10.3390/toxins2061445